§ 06 · THE PAPERS BEHIND THE CLAIMS
GHK-Cu References: the paper behind each claim
GHK-Cu studies listed here run from 1973 to 2024. The links let you check the papers on skin, hair roots, wounds, and lungs.
How the GHK-Cu paper list helps you check a claim
GHK-Cu is a short protein part joined to copper. This page lists each study used for a claim. The number beside a claim matches the number of its paper below.
One research team wrote many of the early papers. Other groups later tested face cream, wounds, hair roots, lungs, and scarring. When a paper is open to the public, its title has a link. You can choose that link when you want to read the study yourself.
Which GHK-Cu findings came from other research teams
Loren Pickart and his team wrote many GHK-Cu papers, starting with the 1973 report. When one team does much of the work, the findings are less sure. Later teams checked some of the same broad claims in their own studies.
Independent work in 1994 tested diabetic foot sores. Studies in 2002 and 2006 tested face cream and care after a CO2-laser. A 2007 dish study tested hair-root cells. Together, these skin and hair papers mostly pointed toward some benefit, though the hair proof stayed thin.
A 2012 study used damaged human lung cells, while a 2022 study used smoke-exposed mice. One 2024 paper tested lung scar cells. Another 2024 paper checked passage through skin, and a 2017 review covered wrinkle work. These studies add support, but they don't replace large human trials.
- Pickart L, Thaler MM. A tripeptide in human serum which prolongs the survival of normal liver cells and stimulates the growth of hepatoma cells. Nature New Biology. 1973;243(124):85-87. ↗
- Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Research International. 2015;2015:648108. ↗
- Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. International Journal of Molecular Sciences. 2018;19(7):1987. ↗
- Pickart L, Vasquez-Soltero JM, Margolina A. The Effect of the Human Peptide GHK on Gene Expression Relevant to Nervous System Function and Cognitive Decline. Brain Sciences. 2017;7(2):20. ↗
- Leyden J, Stephens T, Finkey M, Appa Y, Barkovic S. Skin Care Benefits of Copper Peptide Containing Facial Cream. American Academy of Dermatology Annual Meeting Proceedings. 2002. ↗
- Pickart L, Margolina A. Skin Regenerative and Anti-Cancer Actions of Copper Peptides. Cosmetics. 2018;5(2):29. ↗
- Mulder GD, Patt LM, Sanders L, Rosenstock J, Altman MI, Hanley ME, Duncan GW. Enhanced healing of ulcers in patients with diabetes by topical treatment with glycyl-L-histidyl-L-lysine copper. Wound Repair and Regeneration. 1994;2(4):259-269. ↗
- Pyo HK, Yoo HG, Won CH, Lee SH, Kang YJ, Eun HC, Cho KH, Kim KH. Effect of Tripeptide-Copper Complexes on the Proliferation of Human Dermal Papilla Cells. Biological & Pharmaceutical Bulletin. 2007;30(4):834-838. ↗
- He J, et al. The naturally occurring peptide GHK reverses age-related fibrosis by modulating myofibroblast function. Aging Pathobiology and Therapeutics. 2024;6(4). ↗
- Pickart L, Vasquez-Soltero JM, Margolina A. The Human Tripeptide GHK-Cu in Prevention of Oxidative Stress and Degenerative Conditions of Aging: Implications for Cognitive Health. Oxidative Medicine and Cellular Longevity. 2012;2012:324832. ↗
- Pai V, Bhandari P, Shukla P. Topically applied GHK as an anti-wrinkle peptide. BioImpacts. 2017;7(4). ↗
- Campbell JD, McDonough JE, Zeskind JE, Hackett TL, Pechkovsky DV, et al. A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK. Genome Medicine. 2012;4(8):67. ↗
- Park JR, Lee H, Kim SI, Yang SR. Glycyl-L-histidyl-L-lysine-Cu2+ attenuates cigarette smoke-induced pulmonary emphysema and inflammation by reducing oxidative stress pathway. Frontiers in Molecular Biosciences. 2022;9:929185. ↗
- Czyrski A, Resztak M, Hermann TW, Kus K, Glowka FK. Are We Ready to Measure Skin Permeation of Modern Antiaging GHK-Cu Tripeptide Encapsulated in Liposomes? Pharmaceutics. 2024;16(12):1526. ↗